Efetividade da radioiodoterapia com 131I-metaiodobenzilguanidina (131I-MIBG) para o tratamento do neuroblastoma
نویسندگان
چکیده
Objetivo: Avaliar se a radioiodoterapia com 131I-metaiodobenzilguanidina (131I-mIBG) aumenta sobrevida de pacientes diagnóstico neuroblastoma, mIBG-ávido, refratários ao tratamento ou alto risco para recidiva, independentemente do estadiamento da doença. Métodos: Revisão sistemática literatura. Consultadas as bases Medline (PUBMED), EMBASE e Cochrane Library, sendo incluídos estudos disponíveis em texto completo, publicados nos idiomas inglês, espanhol português. Os desfechos interesse foram global livre progressão Principais Resultados: O pode ser viável tolerável neuroblastoma risco, entretanto, os benefícios deste regime são observados apenas que estavam resposta completa muito boa parcial após quimioterapia indução, antes início 131I-mIBG. Conclusões: Existem incertezas quanto efetividade 131I-mIBG o aumento neuroblastoma.
منابع مشابه
131I-MIBG in the diagnosis of primary and metastatic neuroblastoma.
OBJECTIVE Neuroblastoma is the third most common malignancy of childhood. 131I-MIBG scintigraphy must be performed in patients with neuroblastoma at the time of staging. The aim of this study is to identify the role of 131I-MIBG scintigraphy in neuroblastoma patients in correlation with other diagnostic modalities for staging of the disease. METHODS Twenty six patients provisionally diagnosed...
متن کاملComparing diagnostic performance of 131I-metaiodobenzylguanidine (131I-MIBG) and 99mTc-hydrazinonicotinyl-Tyr3-Octreotide (99mTc-HYNIC-TOC) in diagnosis and localization of pheochromocytoma and neuroblastoma
Introduction: The present study was aimed to assess the diagnostic performance of the two imaging methods of 131I-metaiodobenzylguanidine (131I-MIBG) and 99mTc-hydrazinonicotinyl-Tyr3-Octreotide (99mTc-HYNIC-TOC) in diagnosis and localization of pheochromocytoma and neuroblastoma. Methods: This study ...
متن کاملTumor response and toxicity with multiple infusions of high dose 131I-MIBG for refractory neuroblastoma.
BACKGROUND (131)I Metaiodobenzylguanidine ((131)I-MIBG) is an effective targeted radiotherapeutic for neuroblastoma with response rates greater than 30% in refractory disease. Toxicity is mainly limited to myelosuppression. The aim of this study was to determine the response rate and hematologic toxicity of multiple infusions of (131)I-MIBG. PROCEDURE Patients received two to four infusions o...
متن کامل131I-MIBG in Neuroblastoma, is Not Simply the Uptake in the Primary Mass
Neuroblastoma is the third most common malignancy of childhood. Nowadays, MIBG has become a central procedure for staging and defining extent and location of neuroblastoma tumors. The recommendations of the International Neuroblastoma Staging System (INSS) indicate that MIBG scintigraphy must be performed in patients with neuroblastoma at the time of initial staging and as a followup tool durin...
متن کاملNeuroblastoma imaging using a combined CT scanner-scintillation camera and 131I-MIBG.
UNLABELLED High-dose administration of 131I-metaiodobenzylguanidine (131I-MIBG) continues to be a promising treatment for neuroblastoma. However, currently used methods of estimating 131I-MIBG uptake in vivo may be too inaccurate to properly monitor patient radiation exposure doses. To improve localization and uptake measurements over currently practiced techniques, we evaluated different metho...
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ژورنال
عنوان ژورنال: Research, Society and Development
سال: 2023
ISSN: ['2525-3409']
DOI: https://doi.org/10.33448/rsd-v12i4.40685